Спирулина Spirulina Научные исследования Спирулина в клинической практике: доказательства, основанные на человеческих приложений



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CONCLUSING REMARKS


Recently, great attention and extensive studies have been devoted to evaluate the therapeutic benefits of Spirulina on various diseased conditions including hypercholesterolemia, hyperglycerolemia, cardiovascular diseases, inflammatory diseases, cancer and viral infections. The cardiovascular benefits of Spirulina are primarily resulted from its hypolipidemic, antioxidant and antiinflammatory activities. Data from preclinical studies with various animal models consistently demonstrate the hypolipidemic activity of Spirulina. Although differences in study design, sample size and patient conditions resulting in minor inconsistency in response to Spirulina supplementation, the findings from human clinical trials are largely consistent with the hypolipidemic effects of Spirulina observed in the preclinical studies. However, most of the human clinical trials are suffered with limited sample size and some with poor experimental design. Additional clinical trials with large sample size and high quality experimental design are warranted to confirm the hypolipidemic benefits of Spirulina in various target human populations.

The antioxidant and/or antiinflammatory activities of Spirulina have been demonstrated in a large number of preclinical studies. However, a limited number of clinical trials have been carried out so far to confirm such activities in human. Future clinical trials are required to establish the antioxidant and antiinflammatory benefits in human. In addition, efforts should be taken to standardize the dose of Spirulina in future human clinical studies. Spirulina is generally considered safe for human consumption supported by its long history of use as food source and its favorable safety profile in animal studies. However, rare cases of side-effects in human have been reported. Additional clinical studies are required to systemically establish the safety profile of Spirulina in human. Quality control in the growth and process of Spirulina is a key measurement to avoid contamination and guarantee the safety of Spirulina products. . Currently, our understanding on the underlying mechanisms for Spirulina’s activities, especially the hypolipidemic effect, is still limited. Future studies to identify the active ingredients in Spirulina and uncover the mechanistic insights into Spirulina’s therapeutic effects will provide the bases for developing new drugs for preventing or treating hypercholesterolemia and cardiovascular diseases.



Защитный эффект полисахарид из Спирулины платенсис на дофаминергические нейроны в МФТП-индуцированного Паркинсонизма в модели мыши c57bl/6 дней мышей.

Настоящее исследование было проведено с целью определить, является ли полисахарид получен из Спирулины платенсис показывает защитное воздействие на дофаминергические нейроны. С болезнью Паркинсона, модель была создана путем внутрибрюшинного введения 1-метил-4-фенил-1,2,3,6-тетрагидропиридина (МФТП) в С57BL/6 дней мышей. До инъекции МФТП, некоторых мышей были подавить с помощью внутрибрюшинной инъекции полисахарид, получаемый из Спирулины платенсис раз в день в течение 10 дней. Результаты показали, что иммунореактивного окрашивания и экспрессии мРНК данного транспортера допамина и тирозин гидроксилазы, лимитирующим ферментом в синтезе дофамина в черной субстанции, существенно увеличивался у мышей, предварительно с 800 мг/кг полисахарида по сравнению с МФТП-обработанных мышей. Деятельность супероксиддисмутазы и глутатионпероксидазы в сыворотке крови и средним мозгом были также значительно увеличилась в введении мышам МФТП после предварительной обработки с полисахаридом из Спирулины платенсис. Напротив, активность моноаминоксидазы-б в сыворотке и средний мозг сохраняется неизменным. Эти экспериментальные результаты указывают на то, что полисахарид получен из Спирулины платенсис играет защитную роль против МФТП-индуцированного потеря дофаминергических нейронов в С57BL/6 дней мышам, и, что антиоксидантные свойства этого полисахарида, вероятно, лежат в основе его нейропротекторное действие.



Neural Regen Res. 2015 Feb;10(2):308-13. doi: 10.4103/1673-5374.152387.

Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson's disease model in C57BL/6J mice.


Zhang F1, Lu J2, Zhang JG3, Xie JX4.

Author information


  • 1Department of Pharmacology, Medical College of Qingdao University, Qingdao, Shandong Province, China.

The present study aimed to determine whether a polysaccharide obtained from Spirulina platensis shows protective effects on dopaminergic neurons. A Parkinson's disease model was established through the intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6J mice. Prior to the MPTP injection, some mice were pretreated with intraperitoneal injections of a polysaccharide derived from Spirulina platensis once daily for 10 days. The results showed that the immunoreactive staining and mRNA expression of the dopamine transporter and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra, were significantly increased in mice pretreated with 800 mg/kg of the polysaccharide compared with those in MPTP-treated mice. The activities of superoxide dismutase and glutathione peroxidase in the serum and midbrain were also increased significantly in mice injected with MPTP after pretreatment with the polysaccharide from Spirulina platensis. By contrast, the activity of monoamine oxidase B in serum and midbrain maintained unchanged. These experimental findings indicate that the polysaccharide obtained from Spirulina platensis plays a protective role against the MPTP-induced loss of dopaminergic neurons in C57BL/6J mice, and that the antioxidative properties of this polysaccharide likely underlie its neuroprotective effect.



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